The lupus anticoagulant: preparation, surrender, decoding, meaning for men, women, pregnant women. The lupus anticoagulant is negative, weakly positive, increased: what is it?

A person in his life is brought to undergo many medical examinations, passing a variety of tests. What is a blood test for sugar or, for example, for cholesterol, everyone knows, but this is what a blood test for the lupus anticoagulant is known.

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Meanwhile, the presence of the lupus anticoagulant in the blood should alert. Why? This is what will be discussed.

What is a lupus anticoagulant in a blood test?

Wolf anticoagulant There are antibodies that interact with some antigens of the human body. Such antibodies are usually called autoantites, and in such interaction they begin to fight their own phospholipids and proteins associated with them - i.e. almost counteract their own immunity.
The lupus anticoagulant belongs to immunoglobulin, most often belonging to the class G. Launching a reaction of confrontation with phospholipids in the body, it begins negatively influence blood coagulation processes, Violating them and leading to a significant slowdown in the formation of bloody clots that prevent significant blood loss. It's believed that normally, the lupus anticoagulant is practically absent.
If similar anticoagulant It is detected in a blood test, this indicates that with an increase in the time required for coagulation, in the blood (both in veins and in arteries) may begin Active cloak formation, Moreover, this can happen in absolutely any organs and parts of the body, which often becomes the cause of heart attacks, pulmonary embolism, miscarriages.

Wolf anticoagulant: Does it change throughout life?

A healthy person should not have a lupus anticoagulant. And if the state of health throughout life does not undergo significant changes, then this indicator remains unchanged. But with a disease, for example, a systemic lupus erythematosus, the number of lupus anticoagulant approximately 30-40% of patients increase.
Doctors noticed that the level of data from antibodies begins to grow after a person has suffered an infectious disease, since autoimmune processes begin in the body. In addition, the lupus anticoagulant sometimes rises in women preparing to become a mother. The presence of a lupus anticoagulant is also characteristic of proceeding inflammatory processes, with HIV infection, individual types of oncology.
Thus, since the above diseases are not congenital, but acquired, we can say on a change in the level of the lupus anticoagulant throughout life.

Which doctor treats the lupus anticoagulant?

Assigning an analysis according to their profile can gynecologists, immunologists, cardiologists And, of course, therapists observing the patient. If the analysis was passed without the direction of a narrow specialist, and as a general examination of the body, for example, during pregnancy, then first you need to contact your attending physician. He will determine how dangerous (or not dangerous) the indicators are obtained and will give recommendations.
Directly with the treatment in the presence of a lupus anticoagulant is engaged in revatologist, specializing in pathologies due to autoimmune diseases of the connective tissues.

Blood for lupus anticoagulant: preparation, on what day to take the cycle?

To properly prepare for Blood donation for lupus anticoagulant and exclude errors as a result, it is necessary to take food for at least 8 hours before blood donation so as not to provoke metabolic processes in the body, changing the concentration of enzymes and substances. You can drink water, but no more than a glass.
A day before the analysis should be exclude fatty foods In order not to increase fat components in the body. The same applies to alcohol intake - it must be excluded.
Smoking ceases at least an hour before the analysis, since the resin included in the tobacco smoke affect platelets. It is necessary to warn the doctor in advance if you take any drugs, including bIODOTS - They can also affect the reliability of the result, and only the doctor will determine what can be continued and what must be canceled before blood donation.
Blood for lupus anticoagulant It is necessary to take in a calm relaxed state, do not engage in this sports and do not perform hard physical work.

Women should donate blood on certain days of the menstrual cycle. It can be fifth, seventh or tenth day - It depends on what duration the cycle has. In general, the analysis is passed in the first third of the cycle. It is necessary to pay attention to the smearing discharge - if they are present, the analysis is better to transfer.

How many days is the analysis for the lupus anticoagulant prepared?

The time of research in different clinics and laboratories is different. It depends on urgency - then analysis for lupus anticoagulant it is prepared within one day, including after 2-5 hours.
The average time for the manufacture of analysis - 1-2 days. In separate clinics that do not have their own laboratories, the time for determining the result may be 5-8 days.

Wolf anticoagulant decoding analysis in seconds

The standard indicator (it is called reference value) during screening is from 31 to 44 seconds, And with a confirming sample, the result representing the norm is in the interval from 30 to 38 seconds.

The index, demonstrating the risk of the lupus anticoagulant, is determined in conditional units that correlate with this value, and is:

Lack of risk - from 0.8 to 1.2
The risk is mild - from 1.2 to 1.5
Moderate indicator - from 1.5 to 2.0
Strong risk - over 2

Wolf anticoagulant during pregnancy Norm by week

As a rule, an analysis for the content of the lupus anticoagulant is carried out if there are indications, including pregnancy. Usually, if there is a threat of miscarriage, the doctor prescribes a sample for this anticoagulant twice, the break between them is from 6 to 8 weeks.

If we talk about a detailed coagulogram that studies the coagulation of blood, then the norms during pregnancy are:

From 13th to 21st week-0.56-1.1
From 21st to 29th week-0.5-1.13
From 29th to 35th week-0.58-1.17
From 35th to 42nd week-0.15-1.14

Wolf anticoagulant: how many times to take?

There is a certain established algorithm that has developed an international society dealing with problems of thrombosis and hemostasis.

It implies three stages of analysis for the lupus anticoagulant:

Screening analysis is performed, considering lengthening phospholipid -dependent coagulation studies.
A test-correction, which is aimed at finding out the reason for the violation of screening indicators.
The final testwhich establishes the character of the inhibitor.

Analysis period for lupus anticoagulant

Each analysis, including the presence of a lupus anticoagulant, has a certain period during which they are considered relevant.

The analysis passed to determine the indicator of the lupus anticoagulant is valid for a month. After this period, it must be re -taken, if necessary.

Wolf anticoagulant: the norm when planning pregnancy

Delivery of the analysis for the availability wolf anticoagulant when planning pregnancy It is mandatory. In this case, the standard indicator is considered the norm, not exceeding 1.2. In the event that the value is higher, then before deciding on motherhood, it is necessary to find out the reason for the increase in the indicator of the lupus anticoagulant, and eliminate it so as not to expose the risk of either their own health or the intrauterine development of the baby.
If you do not get rid of the disease that affects the value of the lupus anticoagulant, the risk of termination of pregnancy or pathologies in the development of the embryo is extremely high - up to 95%. Therefore, the test for these antibodies must be carried out, and in the future, repeated studies periodically undergo.

The lupus anticoagulant is negative: what does this mean?

A healthy person should not have blood components like the lupus coagulant, therefore, in the case when the analysis shows the result is from 0 to 1.2, they talk about the negative result. This means that the lupus coagulant is not at all determined in the composition of the blood, or its content is within the permissible norm. In this case Doctors exclude the possibility of autoimmune pathology, as well as antiphospholipid syndrome.
At the same time, it is recommended to conduct a blood test in several stages so that repeated samples confirm the absence of a lupus coagulant. It is the result that is determined by two analyzes that is considered negative.

The lupus anticoagulant is weakly positive: what does it mean?

When a woman plans a pregnancy or is already in this pleasant state, she periodically passes various tests, among which there is a definition of blood for the presence of a lupus anticoagulant.
There is a gradation of conditional units, according to which the indicator up to 1.2 is the norm. If the analysis shows the result slightly higher (but not higher than 1.5), doctors define such a result as a slightly positive.
This indicator demonstrates the presence of a lupus anticoagulant in the composition of the blood, but its activity is quite low, which, however, it does not cancel the need to search for the causes of increasing the content of the anticoagulant and their elimination.

Lupus anticoagulant - confirming the test of a slightly positive

Coagulation test for the detection of lupus anticoagulant It is a screening during which a longer time of blood coagulation can be explained by a wide variety of reasons: from the actual presence of the wolf anticoagulant and its other “colleagues”, such as Heparin or warfarin, to a deficiency of factors affecting coagulation.
To find out how much the wolf anticoagulant itself affects this process, and the confirming sample is necessary when the reagents in which phospholipids are added. If there is a normalization of the time during which blood coagulation occurs, it means that the lupus anticoagulant has the effect.
If time is not reduced, then other factors that can have an influence on it are alternately checked. To exclude this influence as much as possible, some time before testing is necessary stop taking quarrels and exclude heparin.

The lupus anticoagulant is increased: reasons, why is it dangerous?

Increasing the content of the lupus anticoagulant in can be due to diseases such as antiphospholipid syndrome, rheumatoid arthritis. It is possible to increase this component with a systemic lupus erythematosus or multiple myeloma, as well as with non -specific ulcerative colitis.
A positive result is not excluded in the presence of neoplasms. And, finally, the reason for increasing the concentration may be the body's reaction to individual medicinal substances that were used to treat any disease.
For a pregnant woman, such a diagnosis fraught with infertility or miscarriage. The fading of pregnancy or the birth of a non -viable child is not excluded. There is a threat to the life of the mother herself. In addition, an increase in the lupus anticoagulant that can provoke increased thrombosis can to lead to strokes and heart attacks, to affect the lower limbs, to manifest as thromboembolism.

Especially dangerous is the increased content of the lupus anticoagulant for those who suffer from thrombosis or cardiovascular diseases, in cases of existing brain disorders or lack of platelets, in the presence of hemolytic anemia and antiphospholipid syndrome.

How is the lupus anticoagulant treat if it is increased?

Drugs prescribed by a doctor for treatment of lupus anticoagulant, depend on the amount of antibodies, the presence of thrombosis in history, etc. At the same time, if the bloodboard did not occur before, then it may not have to resort to therapy.
Basically, therapy provides for anticoagulants by type Heparin, warfarin or aspirin, slowing down the process of producing vitamin K, which occurs in the liver, and, as a result, the time required for blood coagulation. The duration of treatment is individual, from several months to constant administration throughout life, and depends on the results of the analyzes that is carried out during treatment.

It is possible to reduce the level of antibodies The appointment of steroids by the type of prednisone, cortisone, methyl -subject. It may be necessary to pass the plasma exchange procedure (or plasmapheresis), in which the affected plasma with a high -quality or its substitute occurs.
From the "home" treatment methods, careful monitoring of other drugs taken is necessary that can provoke the appearance of the lupus anticoagulant. After consulting a doctor, some of them may have to be canceled.
To improve blood circulation, it is vital to quit smoking, abandoning alcohol and reducing overweight, and to strengthen the cardiovascular system-to engage in physical exercises.

Wolf anticoagulant in men

Most often the wolf anticoagulant It is manifested in the form of antiphospholipid syndrome, and thrombosis, in particular venous, is the most characteristic manifestation in men. Perhaps also a manifestation in the form ischemic strokes, headaches.

The heart may be affected, which is expressed by the risk of myocardial infarction, which is more often characteristic of men who have not reached the age of 50. The lupus anticoagulant is also expressed by the fact that the heart valves are affected, arterial hypertension develops. Often the skin, which is covered with a vascular mesh, is also possible to gangren fingers of the extremities.
It is also possible to increase the liver due to the affected vessels, liver enzymes can have a denser concentration, and in the peritoneum can Accumulate liquid, leading to ascite.
Signs of the presence of lupus anticoagulant In men, early thrombosis can serve, including intestinal vessels, for which thrombus is uncharacteristic. A very high risk in men with such a disease as a systemic lupus erythematosus. An indicator can also be a low number of platelets in the absence of diseases associated with blood.

Wolf anticoagulant and infertility

Wolf anticoagulant and antiphospholipid syndrome - A common cause of female infertility.

Antibodies opposing phospholipids, which is the lupus anticoagulant, are one of the causes of blood clots in the vessels of the placenta. This, in turn, leads to a violation of the power of the embryo, as a result of it, a fading of pregnancy, the pathology of the development of the fetus and its intrauterine death, to the detachment of the placenta itself are possible.

In the presence of a lupus anticoagulant, about 85% of pregnant women have complications during the gestation of a child, often ending with spontaneous abortion. Thus, what doctors call the usual miscarriage.
In the absence of treatment, almost 100% of pregnancies become problematic. Therefore, already at the stages of pregnancy planning, it is necessary to undergo a comprehensive examination of the body and be sure to take an analysis for the presence of a lupus anticoagulant.

How does the lupus anticoagulant affect the implantation of the embryo?

With an increased content of the lupus anticoagulant during pregnancy, the fetal bearing becomes difficult. A spontaneous abortion and premature birth can happen, the fetus may have a delay in its development, even the intrauterine fading of the embryo is not excluded.
because of thrombotic action of the lupus anticoagulant It is possible to defeat vascular thrombosis contained in the placenta, the miscarriage of the embryo, a delay in its growth. If the influence is non -brown in nature, then the onset of pregnancy is difficult, since the implantation of the embryo is disturbed, which cannot gain a foothold and, accordingly, develop.

How to treat lupus anticoagulant during pregnancy?

If a A wolf coagulant was found in the blood of a pregnant woman, The doctor, before prescribing treatment, studies the results of many tests and examinations that the expectant mother must pass. Among them, the definition of antibodies in relation to cardiolipin, a coagulogram is necessarily controlled.
Starting from the second trimester, the liver and kidneys are mandatory to determine the indicators demonstrating how much the body contains creatininas well as cholesterol with urea. In addition, it is shown monthly ultrasound study, controlling the process of fetal development, and dopplerometry, determining the presence of risks. Also, a pregnant woman should consult a hematologist and geneticist.

Consultation with a specialized specialist is important

Only on the basis of the results of all examinations is treatment. Preparations that are usually used to reduce antiphospholipid syndrome, it is possible to prescribe Heparin, aspirin or warfarin. To eliminate problems with autoimmune processes and to treat rheumatic pathologies, glucosteroids are prescribed. To reduce the excessive amount of antibodies in the blood, the doctor may prescribe plasmapheresis. As a rule, the course of treatment reaches three months, while regular blood tests for the presence of a lupus anticoagulant are needed.

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