The effectiveness of metronidazole in the treatment of acne on the face: the mechanism of action of the antibiotic, does it help, recipes of masks, chatterboxes, masks

Read on our website an article on the topic: "The use of isolatinoin in severe acne forms, acne". You will learn about the effectiveness of treatment and side effects.

Metronidazole From acne is prescribed in the form of external products (gel, cream, masks, etc.) or tablets for oral administration. Read more more.

The causes of acne on the face

The root cause of the occurrence of acne and subcutaneous acne on the face is the clogging of the mouth of the sebaceous gland with a mixture of dirt, keratinized skin cells and sebum (skin fat).

• With acne, the own bactericidal activity of the sebum falls, so the contents of the clogged pores become a beneficial environment for the propagation of bacteria.
• Most often, sebaceous glands and hair follicles find optional anaerobes - Propionibacterium Acnes, Staphylococcus spp. and Streptococcus spp.
• The development of bacterial colonies and the secretion of microbes vital products provokes an inflammatory reaction.
• In the skin cells, histamine and other inflammation mediators are released, which attract leukocytes to the place of accumulation of pathogenic microflora.

Closed acne (white suppuration) are formed due to the protective reaction of immunity. The main goal of this mechanism is to prevent the spread of infection. Massive inflammation leads to the development of nodal and drain acne. They are the most serious forms of acne.

Open acne (black dots) arise due to the accumulation of keratinized cells. The color of the clogged pores is due to the pigment with melanin.

Composition and form of release of the drug metronidazole for acne: gel, cream, ointment, Trichopolis tablets

For acne and acne, metronidazole preparations are used in several dosage forms. Here is a description of their composition and methods of application:

Tablets:

• This form of the antibiotic can be used orally (inside) or externally (as part of homemade masks, lotions and tonniks from acne).
• Tablets Metronidazole contain 250 mg of the active component. Additional components are titanium dioxide, talc, gelatin, lactose and gipromellose, cellulose, starch, propylene glycol and magnesium stearate.
• Treatment with tablets should be combined with local application of the antibiotic.

Gel:

• The antibiotic is part of the metrogil gel.
• This drug is available in 3 forms, which are designed for application in the oral cavity (dent metrogil), in the vagina and the skin (external).
• With acne, only the external gel is prescribed.
• The concentration of the active substance in the drug is 1%.
• In addition to the antibacterial component, the composition includes water, sawn and methyl parahydroxybenzoate, propylene glycol, Edt, sodium alkali and carbomer.

Cream or ointment:

• Metronidazole It is the current component of Rosex and Rosamet creams.
• The concentration of the antibiotic in the first drug is 0.75%, and in the second - 1%.
• Creams or ointments with metronidazole have a denser structure than gel.
• They are used mainly for the treatment of acne on combined or sensitive skin.

With complications of acne, antibiotic injections can be prescribed. Concentration metronidazole In a solution for injection is 5 mg per 1 ml.

It is worth noting that the price Metronidazole low and amounts to only 15-20 rubles. For 20 tablets. The cost of the metrogil gel for external use starts from 159 rubles. For 30 g. The price of the rosamet cream (1% metronidazole) is from 191 rubles. For 25 g. As you can see, for a low cost you can get an effective medicine for acne.

The mechanism of action of the antibiotic metronidazole: Does acne on the face help?

Does the antibiotic helps Metronidazole from acne on the face?

• The mechanism of the anti -Great effect of the drug is unknown, because This antibiotic is ineffective regarding optional anaerobes.
• It does not show antiparasitic effects in relation to the Demodex folliculorum tick, which can cause or complicate acne.
• The antimicrobial effects of a substance are manifested only in relation to anaerobic bacteria (eubacteria, clostidia, peptobastroptococci, etc.).

The positive effect of the treatment of metronidazole for acne can be due to the following factors:

• Synergistic effects with other antibiotics. Without exerting antimicrobial effects on aerobic bacteria, metronidazole enhances the antibacterial effect of other drugs (including penicillins, macrolides, etc.). The synergistic effect is manifested mainly with the mixed composition of microflora (aerobic + anaerobic bacteria).
• Antioxidant activity (with external use). The antibiotic reduces the production of peroxide hydrogen, hydroxyl and oxygen radicals with neutrophils. These compounds are potential oxidants that can damage the skin cells at the site of inflammation.
• Correction of gastrointestinal microflora (when taking orally). Diseases of the gastrointestinal tract, including Excess reproduction of pathogenic microflora is a risk factor in acne.

Metronidazole It can be used as monotherapy (for anaerobic flora) or in combination with other drugs: for example, amoxiclava or clarithromycin.

Metronidazole from acne - Instructions: Indications for use

Indications for the use of drugs based on metronidazole From acne are:

• Rosacea, including Against the background of steroid therapy, the drug is ineffective against redness and vascular nets that appear at the first stage of the disease.
• Vulgar acne (acne).
• Long -free skin wounds, infectious diseases of the epidermis and secondary infections, including With damage to acne.
• Seborrhea and other pathological conditions of the skin, which are accompanied by a change in the composition of the sebum.

For oral administration:

• Skin and soft tissue infections
• Gastrointestinal tract lesions that worsen the condition of the skin-gastritis, peptic ulcer of the stomach and 12-perimal intestine, intestinal inflammation caused by antibiotic therapy

In general, such a drug can be used for most skin problems. We continue the description of the instructions of this antibiotic. Read further.

Metronidazole: Contraindications for treatment

The external use of metronidazole is contraindicated in treatment in the following conditions:

• Hypersensitivity to antibiotics Or additional components of gel, cream or other tools.
• 1 trimester of pregnancy, breastfeeding (with caution).
• Data on the safety of metronidazole in children is not enoughTherefore, pediatricians prescribe the drug with caution or replaced with permitted analogues.

The antibiotic is practically not absorbed through the skin and does not have a systemic effect on the body with external application. In the 2nd and 3rd trimester of pregnancy, its application is allowed. In the 1st trimester of bearing and during lactation, the drug is used under the supervision of a doctor or replaced by a safe analogue.

Reception metronidazole Inside is still contraindicated in the following cases:

• Allergy to the antibacterial component and additional components of tablets and a solution for injection.
• Violations of the composition of the blood (leukopenia, neutropenia, etc.).
• Porfiry and other diseases of the hematopoietic organ.
• Violation of the liver function (dosage correction is necessary).
• Epilepsy, chronic neurological pathologies (examination by an observant doctor is required).
• Age up to 18 years (with a combination of metronidazole + amoxicillin).

It is worth knowing: Pregnant in the 2-3 trimester of bearing the drug is prescribed only for life indications. With acne, safer antibiotics are selected, because The course of treatment is long.

Metronidazole It penetrates well through the placental barrier and into breast milk, so its use during the laying of the main systems of the child's body (in 1 trimester) is strictly prohibited. Nursing women need to transfer the baby to artificial feeding or use safer products (penicillins, cephalosporins, erythromycin).

Antibiotic metronidazole: side effects

With external antibiotic application Metronidazole The following side effects may occur:

• Allergic rash (urticaria, dermatitis)
• Redness (hyperemia) and peeling in the processed area
• Burning and irritation of the skin
• When getting to the eye: burning, redness of the eyeball, active lacrimation
• When applying cream and gel to areas with a large area (for example, while treating acne on the face and body), systemic side effects are possible. In this case, when choosing an antibiotic, internal contraindications should be taken into account.

When taking inside Metronidazole can provoke the following reactions:

• Nausea, decrease in appetite, vomiting
• Diarrhea, constipation
• Dry mouth, inflammation of the oral cavity (stomatitis, glossitis)
• Pancreatitis
• Change in urine color (acquires a red-brown tint), violation of discharge (polyuria, dysuria),
• Inflammation of the bladder
• Candidiasis
• Joint pain
• Violations of coordination of movements, involuntary muscle movements (ataxia)
• With prolonged therapy and a high dosage of the antibiotic, numbness and weakness of the limbs (peripheral neuropathy) appears
• Headaches, dizziness, short -term fainting, confusion, with a large dosage of metronidazole, epileptiform seizures are possible
• Disorders of sleep and mood (depressive state or increased excitability, irritability)
• ECG Change (Reducing T-Subz)
• Blood disorders (decrease in concentration of leukocytes, neutrophils)
• Skin hyperemia, rash
• Nasal congestion, fever, malaise (allergic genesis reactions)

Metronidazole blocks ethanol oxidation, provoking the accumulation of acetaldehyde. This means that when taking the medicine together with alcohol, toxic reactions occur:

• Stomach ache
• Redness of the face
• Nausea and vomiting
• Farcation of heart rhythm
• Falling blood pressure
• General weakness

During therapy, it is recommended to completely eliminate the use of alcohol.

Metronidazole - tablets, gel, acne ointment: how to take, dosages

Externally antibiotic Metronidazole Applied 2 times a day. The duration of the course is determined individually and can be up to 2-3 months. How to take pills, what dosages? How to apply an ointment?

Before applying a cream or gel, you need:

• Using cosmetic milk, tonic or two -phase emulsion, cleanse the face of decorative cosmetics.
• Wash with a remedy (foam, gel) with soft surfactants.
• Gently smoke your face and wait for the skin completely dry (between the cleansing of the epidermis and the application of the antibacterial agent should pass at least 15 minutes).

With single inflammation, the external agents are applied pointwise, and with an extensive acne - gels and ointments are evenly distributed throughout the face with a thin layer.

Drink antibacterial tablets:

• It is necessary twice a day.
• To reduce side effects, it is recommended to consume them during or after eating, washed down with warm water or milk.
• The duration of the average course of treatment is 1-2 weeks.
• After a monthly break, the doctor may prescribe repeated therapy.

Metronidazole tablets are used not only strictly according to the instructions, but also for the preparation of external antibacterial agents for acne (lotions, tonics, masks, etc.). Before using recipes, you need to consult your doctor.

Losion and tonics with a acne metronidazole: how to cook a talker?

The most gentle product is a lotion or tonic prepared from tablets Metronidazole water based. How to make such a chatterbox?

To prepare the drug, you will need:

• 4-5 antibiotic tablets
• 100-150 ml of pure boiled water (you can take sterile for injection)

The tablets should be crushed into small powder, pour water and shake thoroughly. Wipe your face with a lotion 1-2 times a day immediately after cleansing and drying the skin. To ensure a uniform composition of the suspension, it must be shaken before each use.

For acne, more concentrated antibacterial tonics (“talkers”) are also used. With single acne, they are applied pointwise, on areas of inflammation, and with an extensive acne - on the whole face. The following funds are the most effective:

• With dimexide. Grind 2 antibiotic tablets and dissolve it in 1-2 tbsp. warm water. Add 50 ml of dioxidine (5 ampoules), 2 tbsp. alcohol solution of salicylic acid (2%) and 1 tbsp. Dimexide. Mix the product thoroughly and wipe it with inflammation places once a day (before bedtime).

• With levomitsetin. Take 4 tablets of levomicetine and metronidazole, grind them and mix the powders thoroughly. Pour a mixture of antibiotics with a glass of salicylic alcohol (2% acid). Eat and leave in a closed container for several hours. After that, use the same solution. The alternative recipe for “talkers” with leftomacetin includes 1-2 tablets of both antibiotics and 40 ml of camphor alcohol.

• With calendula. Grind 2 tablets of metronidazole and streptocide. Pour the powder 30 ml (1 bottle) of water or alcohol tincture of calendula or salicylic alcohol. With severe inflammation, it is necessary to use calendula, and with increased oily skin and peeling - salicylic acid.

Concentrated tonics with metronidazole intensively dry the skin, so after applying the talkers, it is necessary to lubricate the face with a moisturizing cream for problem skin or metrogil gel. The duration of the use of antibacterial lotion and tonic should be coordinated with a doctor (cosmetologist or dermatologist).

Antibacterial masks with acne metronidazole: recipes

Antibiotic -based masks Metronidazole allow you to dry acne and acne, relieve inflammation and reduce the oily skin. The most effective are the following compositions - recipes:

With cosmetic clay:

• 2 tablets of the antibiotic thoroughly stop and mix with 2-3 tsp. White clay (kaolin).
• Dilute the resulting powder with warm drinking water, infusion or decoction of calendula. The consistency of the finished mass should resemble light cream or thick cream.
• Apply to peeled skin in several layers, leave for 15-20 minutes.
• To prevent clay drying every 3-5 minutes, spray your face with calendula infusion or thermal water.
• Then remove the main part of the product using a wet cotton pad, and rinse the remains with running water.

With boric acid:

• Pull 2 \u200b\u200bantibacterial tablets and mix them with 1-2 tsp. children's update.
• Add 5 drops of boric acid solution (2%) and 1 tsp. hydrogen peroxide (3% peroxide).
• If necessary, pour a little clean water to achieve a convenient consistency of the product.
• Apply the mask on the face and leave for a quarter of an hour.
• After this time, remove the dried pieces of substances, and rinse the remains with warm water.

Advice: To increase the efficiency of masks with metronidazole, you should combine them with streptocide.

To quickly get rid of acne, you can mix Tetracycline ointment and gel Metrogil. The finished product is well absorbed into the skin, quickly relieves inflammation and destroys the mixed flora. It is recommended to apply pointwise.

With a fat and combined skin, a mask with metronidazole can be done every other day, and with dry - not more than 1 time in 3 days. In breaks, you can apply masks with chlorhexidine. This drug is a local antiseptic, which has an antimicrobial effect on aerobic and anaerobic cocci, some viruses, protozoa and fungi. To prepare the Kaolin mask or other cosmetic clay, it is necessary to dilute with a 0.5% solution of antiseptic.

It is worth knowing: The average duration of the course of masks is 2-3 weeks.

Analogs of the metronidazole from acne

Analogues of external products with metronidazole from acne are:

• Tetracycline ointment
• Gels Dalacin, Clindovit and Klenzit C (antibacterial component - clindamicin, adapalene is additionally included in the composition of the Klenzite, which accelerates the regeneration and exfoliation of the skin)
• Syntomycin ointment
• Mirror solution (antibiotic - clindamycin)
• The solution of Zinerit (erythromycin has an antimicrobial effect, and zinc acetate - dry and anti -inflammatory)
• Levomekol ointment (antibacterial component - levomicetin, healing - methyluracil)
• Erythromycin ointment (this tool based on macrolide antibiotics is used mainly in ophthalmology, but can also be prescribed for the treatment of acne)
• Effezel gel (contains basyron/benzoid peroxide, which is effective against propionobacteria acne, and adapal)
• Baneocin ointment (the product includes 2 antibacterial components: polypeptide antibiotic bacitrasin and aminoglycoside neomycin).

When prescribed, the dermatologist takes into account the sensitivity of pathogenic microflora to other antibiotics and the composition of the drug. The drugs for acne are drugs based on clindamycin and benzoid peroxide. With acne, it is recommended to use light creams and water -based gels. They contain a minimum amount of comedogenic components (paraffin, mineral oils, lanolin, etc.).

Metronidazole from acne: reviews

The disadvantage of the drug metronidazole for acne is side effects: some patients complain of skin irritation, nausea and diarrhea. Reactions from the stomach and intestines are observed with internal use. Many people note that acne completely leaves only after they cure the main cause of oily skin - stagnation of bile. With the regular use of hepatoprotectors and choleretic drugs, the need for antibacterial gels disappears completely. Here are reviews about this drug:

Svetlana, 30 years old

I work as a cosmetologist and often use metronidazole for the treatment of patients. It is intended for the treatment of acne and bacterial skin diseases. The drug is available in several pharmacological forms, therefore it is suitable for both system and local use. Most often I prescribe it in the form of a gel (metrogil). It relieves inflammation well, affects the root cause of the appearance of the rash and minimizes the occurrence of scars. In addition to other advantages, the gel has a low cost. With extensive inflammations or to enhance the effect of the gel, antibiotic tablets are also prescribed.

Tatyana, 32 years old

2 years ago, purulent acne, acne with white heads and point red inflammations began to appear. I began treatment in the fall, when the skin ceased to actively secrete fat and was well dried with antiseptics. To get rid of acne, I used various antibacterial gels and creams. On the recommendation of friends, I bought metrogil: I wanted to quickly get rid of acne, and the antibiotic was supposed to work against bacteria. Later, I found the opinion of a dermatologist that the metronidazole (active substance of the gel) is useless against bacteria and parasites that provoke the occurrence of a rash. I applied metrogil daily in the morning and evening immediately after the cream against the Demodex tick. For 2.5 weeks of treatment, I did not see the effect: acne appeared with the previous frequency, and the current ones did not decrease. The combination of the veterinary drug Amit and Effezels turned out to be more effective. They should apply them once a day, in the evening, because Dimexide in the composition of Amita irritates the skin, and adapalene causes severe peeling. In the morning, she wiped her face with a solution of chlorhexidine, applied a gel with an antibiotic, and after a while - a sulfur gel demotene. Metronidazole also helped.

Elena, 29 years old

I have combined skin on which acne and acne often occur. To get rid of pustules and inflammations, I used to use antibacterial gels (Clindivot, Dalacin, etc.). These funds were not cheap, although with regular application, white acne and spot inflammation were quickly removed. The dermatologist advised a cheaper way out of the situation - antibacterial masks. They are prepared at home from inexpensive antibiotic tablets (metronidazole). The tablets should be chopped, mixed with blue or white clay, and then dilute with water and spread on the face. After half an hour, the mask can be removed with your fingers or a wet sponge. Only the skin “hedgehog”, which I remove with a scrub, remains in the place of acne and acne. After a mask for moisturizing and an additional antibacterial effect, I apply a metrogil gel.

Maria, 34 years old

Saw metronidazole as prescribed by a dermatologist 5 years ago. My main problem at that time was gastritis, which was complicated by an acne. The purchased antibiotic is effective in relation to both problems, because The cause of gastritis is also bacteria. The course of treatment lasts 10 days, after which you need a break of 10-12 days and a second course. In total, I drank 3 courses of metronidazole. In the early days immediately after taking, nausea and slight dizziness occurred, but the dermatologist explained that adverse reactions appear because I take an antibiotic on an empty stomach. If you drink tablets after eating, the symptoms are almost invisible.

The effectiveness of treatment with acne metronidazole: photo before and after

The result of treatment Metronidazole Acne is already visible from the 1st procedure, although for a full course you need 8-10 masks every 1-3 days. After 2-3 weeks, small inflammations and acne disappear, white acne ceases to appear, and the clogged pores are cleaned. The cost of the entire course (packaging of clay and tablets) is less than 100 rubles. This is a cheap and effective tool. Look at the photo before and after such an effective treatment:

In parallel with antibacterial therapy, you can apply a hyoxyson and skinny gel on the face. After a few weeks of such complex treatment, the skin will be completely cleansed of acne. At the time of purchase, metronidazole costs less than 100 rubles. For 20 tablets. For the entire period of treatment, 2-3 packages are required depending on the number of courses. This drug is cheap, but effective. And in combination with other means, gives excellent results.

Video: Metronidazole - the use of antibiotics, indications and contraindications

Video: Metrogil - acne won

Video: How to get rid of acne. A strong recipe for acne. (Consult your doctor. Test allergies 24 hours)

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